Certain Options of ArQule, Inc. are subject to a Lock-Up Agreement Ending on 23-SEP-2019. These Options will be under lockup for 91 days starting from 24-JUN-2019 to 23-SEP-2019. Details: The executive officers and directors and certain of other existing security holders have agreed not to sell or transfer any common stock or securities convertible into or exchangeable or exercisable for common stock, for 90 days after the date of the prospectus supplement without first obtaining the written consent of SVB Leerink LLC and RBC Capital Markets, LLC.