HERCULES, Calif. (AP) — HERCULES, Calif. (AP) — Bio-Rad Laboratories Inc. (BIO.B) on Thursday reported fourth-quarter profit of $349.7 million.

On a per-share basis, the Hercules, California-based company said it had profit of $12.14. Earnings, adjusted for one-time gains and costs, were $3.10 per share.

The maker of instruments used in biomedical research posted revenue of $681.2 million in the period.

For the year, the company reported that its loss narrowed to $637.3 million, or $21.82 per share. Revenue was reported as $2.67 billion.

Bio-Rad shares have risen slightly more than 2% since the beginning of the year. In the final minutes of trading on Thursday, shares hit $328.45, a decrease of 29% in the last 12 months.

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