Cibus, Inc. announced that the Company has successfully regenerated plants from single cells in a wheat cultivar. This is a major breakthrough for Cibus as well as for the industry. Wheat is one of the world?s most cultivated crops, and one of the major crops grown in North and South America.

It is a staple in many diets and is responsible for a fifth of people?s caloric intake, making it one of the world?s most important crops. Wheat flour is consumed in breads, pasta, cookies, crackers, confections, among other things. Initially sequenced a mere five years ago, wheat genomes are some of the large of all crops, having more than 16 billion letters (compared to rice with about one billion letters that was sequenced in 2002 and five times larger than the human genome).

They are also very complex with durum wheat comprising the fusion of two genomes and bread wheat from the fusion of three. Given this breakthrough, Cibus intends to develop a family of traits to address the most significant challenges faced by farmers globally for wheat, focusing initially on disease resistance and nitrogen use efficiency. Nitrogen use efficiency is a need in many crops, but particularly for wheat with its enormous, cultivated acreage.

A nitrogen use efficiency trait would have the potential to materially reduce the carbon footprint of the crop while offering better yield with similar fertilization. Fungal diseases cause a significant economic impact in wheat production with cereals representing the large fungicide market. Development of disease resistance traits in wheat offer the promise of protecting yield potential while reducing fungicide use.

Finally, this platform enables the development of improved wheat quality traits, potentially reducing or eliminating allergens such as gluten and even further improvement of the Company?s high fiber wheat. About the Cibus RTDS®-based High Throughput Breeding System: A key element of Cibus? technology breakthrough is its high Throughput Breeding Process (referred to as the Trait Machine?

System.). The Trait Machine process is a crop specific application of Cibus? patented Rapid Trait Development System?

(RTDS). The proprietary technologies in RTDS integrate crop specific cell biology platforms with a series of gene editing technologies to enable a system of end-to-end crop specific precision breeding. It is the core technology platform for Cibus?

Trait Machine: the first standardized end-to-end semi-automated crop specific gene editing system that directly edits a seed company?s elite germplasm. Each Trait Machine process requires a crop specific cell biology platform that enables Cibus to edit a single cell from a customers? elite germplasm and grow that edited cell into a plant with the Cibus edits.

Cibus has Trait Machine platforms developed for canola and rice and has already begun transferring back to customers their elite germplasm with Cibus edits. The traits from Cibus? RTDS-based High Throughput Breeding System are indistinguishable from traits developed using conventional breeding or from nature.

Under the European Commission current proposals, it is expected that products from Cibus? RTDS gene editing platform such as its pod shatter resistance trait and Sclerotinia resistance traits for Winter Oilseed Rape would be considered ?Conventional-like'. Cibus believes that RTDS and the Trait Machine process represent the technological breakthrough in plant breeding that is the ultimate promise of plant gene editing: High Throughput Gene Editing Systems operating as an extension of seed company breeding programs.