Oakville - Cardiol Therapeutics Inc. (TSX: CRDL) (OTCQX: CRTPF) ('Cardiol' or the 'Company'), a clinical-stage biotechnology company focused on developing innovative therapies for inflammatory heart disease, is pleased to announce the commercial introduction of CortalexTM, a THC-free extra-strength (100 mg/mL concentration) oral cannabidiol (CBD) formulation.

CortalexTM is now available across Canada exclusively at Medical Cannabis by Shoppers online portal, a subsidiary of Shoppers Drug Mart Inc., and is the first pharmaceutically produced CBD specifically formulated for the large number of patients who should not be exposed to tetrahydrocannabinol (THC).

There is a growing demand from paediatricians and family physicians for a CBD formulation that does not contain THC. However, most CBD formulations currently available in Canada contain potentially psychoactive levels of THC and are therefore not appropriate for certain patient populations. This is of particular concern in the case of children and young adults under the age of 25 where THC has been linked to a detrimental impact on brain development. It is also a concern in older individuals, such as those who do not wish to risk intoxication because of the requirements of their occupation, or seniors who might already have chronic diseases that limit coordination or cognitive function and who also wish to avoid intoxication. People over the age of 65 now represent the fastest growing segment of the $500 million medicinal cannabinoid market in Canada.

The commercial introduction of CortalexTM now makes it possible for patients to take CBD, without the intoxicating effects associated with THC. Cortalex is manufactured exclusively for Cardiol by Dalton Pharma Services (Dalton). Dalton is a world-class specialty pharmaceutical company with over 30 years of proven experience and expertise in developing and manufacturing important medicines. Dalton's Health Canada approved, FDA registered, cGMP facilities meet the highest quality standards set by the pharmaceutical industry. This quality standard ensures every bottle of Cortalex has a consistent composition and is THC free, providing assurance and comfort to parents, patients, and physicians.

'Shoppers Drug Mart is a trusted brand, and together with our long-standing partner, Dalton Pharma, we are pleased that Medical Cannabis by Shoppers has agreed to offer Cortalex on an exclusive basis nationwide,' said David Elsley, President and CEO of Cardiol Therapeutics. 'Our Cortalex innovation is now available to address the significant unmet needs of patients who should not take THC, while meeting the highest industry standards for product quality and consistency.'

About Cardiol Therapeutics

Cardiol Therapeutics Inc. (TSX: CRDL) (OTCQX: CRTPF) is a clinical-stage biotechnology company focused on developing innovative therapies for inflammatory heart disease. The Company recently received approval from the U.S. FDA for its Investigational New Drug (IND) application to commence a Phase II/III, double-blind, placebo-controlled clinical trial investigating the efficacy and safety of its lead product, CardiolRx, in hospitalized COVID-19 patients with a prior history of, or risk factors for, cardiovascular disease. CardiolRx is an ultra-pure, high concentration cannabidiol oral formulation that is pharmaceutically produced, manufactured under cGMP, and THC-free (

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