Creo Medical : Letter to Shareholders May 2023

26 May 2023

Dear Shareholder,

Creo Medical Group plc ("Company") - 2022 Annual Report and Accounts & 2023 Annual General Meeting.

This letter is to inform you that the following documents are available for your review on the Company's website at www. creomedical.com/investors/reports-and-presentations:

1. Creo Medical Group plc's Annual Report & Accounts for the financial year ended 31 December 2022 (the "Annual Report & Accounts"); and
2. a notice (the "Notice") of the Company's annual general meeting (the "AGM").

AGM

The AGM will be held at the offices of Osborne Clarke, Halo, Counterslip, Bristol BS1 6AJ on 27 June 2023 at 10:00 am.

This letter is a notification only and does not contain the specific details of the resolutions to be tabled at the AGM. Full details of the resolutions to be tabled at the AGM are contained in the Notice and should be read before you complete your vote. Please note that in line with the Pre-emption Group's Statement of Principles issued in 20221, the directors are seeking authority to issue up to 10% of the issued ordinary capital on an unrestricted basis.

The Directors consider that the resolutions to be proposed at the AGM are in the best interests of the Company and shareholders as a whole and unanimously recommend that you vote in favour of the resolutions. Voting will be conducted on each resolution by way of a poll.

Craig Gulliford, the Company's CEO, will make a short presentation at the meeting. No new material information will be included within the presentation.

Proxy voting

Shareholders are encouraged to vote by proxy at the AGM, which can be done:

1. by completing, signing the enclosed Form of Proxy and returning it to Equiniti; or
2. in the case of CREST members, by utilising the CREST electronic proxy appointment service.

Proxy votes must be received no later than 10:00 am on 23 June 2023.

Shareholders are recommended to appoint the Chair of the meeting as their proxy rather than a named person, as any such other person may not be permitted to attend the AGM in the event of unforeseen circumstances (e.g. illness).

If there are any questions, please contact Equiniti's Shareholder helpline on +44 (0)371 384 2030. Lines are open between 8.30am and 5.30pm Monday to Friday excluding UK public holidays.

On behalf of the board of Creo Medical Group plc, thank you for your continued support.

Yours faithfully

Charles Spicer

Chairman

1 www.frc.org.uk/getattachment/cd763f78-d306-43bf-99f7-7fb282200c4d/PEG_Statement-of-Principles.pdf