On December 5, 2022, Diffusion Pharmaceuticals Inc announced that it has sent a letter to shareholders, highlighting the Company board leadership and its performance in strategic review, commented on LifeSci Special Opportunities Master Fund Ltd earlier actions which were impacted on the share price and their ability in strategic review. In addition, the Company urged the shareholders to vote for its board nominees, at the annual meeting of shareholders scheduled to be held on December 30, 2022.