On March 21, 2016, Echo Therapeutics, Inc. issued a promissory note to Platinum Partners Value Arbitrage Fund L.P. (Lender") in the aggregate principal amount of $150,000 in respect of a bridge loan made by such party. The promissory note, which bears interest at the prime rate, may, at Lender's option, be exchanged for securities issued in a subsequent financing by the Company, including the second tranche financing described in the filing with the SEC on February 3, 2016.