On December 5, 2023, John F. Crowley, a member of the Board of Directors (the board) of Entrada Therapeutics, Inc., notified the company of his resignation from the Board, including the Audit Committee of the Board (the Audit Committee), on which he serves as a member, and the Compensation Committee of the Board (the Compensation Committee), on which he serves as the Chair, effective December 5, 2023. Mr. Crowley?s decision to resign from the Board is not due to any disagreement with the company?s operations, policies or practices. On December 5, 2023, effective upon the resignation of Mr. Crowley, the Board appointed Gina Chapman as a member of the Audit Committee and Kush M. Parmar, M.D., Ph.D. as a member and the Chair of the Compensation Committee, to fill the newly-created vacancies resulting from Mr. Crowley?s resignation, until their respective successors are elected and qualified, or until their earlier death, resignation or removal, or until otherwise determined by the Board.