On November?8, 2021, Richard Pascoe stepped down from his position as President and Chief Executive Officer of Histogen Inc. and as a member of the Company?s Board of Directors (the ?Board?). Mr.?Pascoe?s decision to step down as an officer of the Company and a member of the Board was to pursue other opportunities and not the result of any disagreement with the Company on any matter relating to the Company?s operations, policies, or practices. The Board appointed Steven J. Mento, Ph.D., a current member of the Company?s Board of Directors, as Executive Chairman and Interim President and Chief Executive Officer as of November?8, 2021. The Company has entered into an agreement with Dr.?Mento to reflect his new position as Executive Chairman and Interim President and Chief Executive Officer.