Date

Theme

Sector

5 March 2024

Alert

Healthcare

Company

Immutep Limited (IMM)

Dose it higher? Now an option

| Announcement Highlights

Immutep have released initial data from their pilot phase study (n=6) exploring higher dosing of their lead oncology candidate Efti in HR+/HER2-/low metastatic breast cancer patients (mBC). The study tested Efti in combination with chemotherapy at 3x higher dose of Efti than has been used in their prior trials (90mg vs 30mg). New data shows Efti continues to be safe and well tolerated even at this higher dosing with only mild severity AEs reported. This pilot was the lead-in to the larger Phase II/III AIPAC-003 trial in mBC which is now 40% enrolled in the Phase II arm (23/58). Clinically the combination of high dose (90mg) efti plus paclitaxel chemotherapy showed good clinical response with an overall response rate (ORR) of 50% and disease control rate (DCR) of 100% (including 1 complete response patient). This data is consistent with their published Phase IIb AIPAC trial. Important to note, these six mBC patients had exhausted all endocrine therapy options (including CDK4/6 inhibitors) and thus are a challenging patient cohort to treat with such strong initial response rates. Looking more broadly, this data gives IMM dosing optionality across all of their development programs - as they finalise their Phase III TACTI-004 NSCLC trial design expected to be announced very soon.

RecommendationOVERWEIGHT

Dr Melissa Benson

melissa.benson@wilsonsadvisory.com.au

Tel. +61 2 8247 6639

Dr Shane Storey

shane.storey@wilsonsadvisory.com.au

Tel. +61 7 3212 1351

Madeleine Williams

madeleine.williams@wilsonsadvisory.com.au

Tel. +61 3 9640 3834

| Wilsons' View

Initial analysis

Dosing optionality. The key takeaway from this data is really that Efti has an incredibly good safety profile with no significant change in AE profile even at a 3x higher dose. This is not the norm for IO assets, many of which we are seeing have an additive safety burden when in combination with other drugs/chemotherapy. This is a key differentiator for Efti and its future utility as a broad immune booster across oncology indications (and treatment combinations). Whilst the mBC clinical response data is certainly encouraging, the larger commercial relevance of this announcement is around the optionality it grants IMM in their TACTI-004 trial design. With this safety pilot now complete discussions around the use of a 90mg dose in the upcoming Phase

  1. NSCLC trial can be had, we understand with no additional clinical safety data required to support use in TACTI-004. We will have to wait and see what IMM decide to do, and if they stick with 30mg dosing from their Phase II program or opt to boost the dose (to 90mg) in Phase III, which should allow enhanced immune stimulation. IMM are due to announce the finalised TACTI-004 trial design imminently.

Earnings implications

None.

Investment view

We maintain our OVERWEIGHT rating and $0.90/sh risked PT on Immutep. We are bullish on Efti's prospects and opportunity for share price re-rate in the coming 6 months with initial top line data from their Phase IIb TACTI-003 trial in HNSCC anticipated.

Wilsons Advisory Equity Research

Analyst(s) who owns shares in the Company: n/a Issued by Wilsons Advisory and Stockbroking Limited (Wilsons Advisory) ABN 68 010 529 665 - Australian Financial Services Licence No 238375, a participant of ASX Group and should be read in conjunction with the disclosures and disclaimer in this report. Important disclosures regarding companies that are subject of this report and an explanation of recommendations can be found at the end of this document.

5 March 2024

Healthcare

Immutep Limited

Disclaimers and Disclosures

| Recommendation structure and other definitions

Definitions at wilsonsadvisory.com.au/disclosures.

| Analyst certification

Each analyst of Wilsons Advisory and Stockbroking Limited (ACN 010 529 665: AFSL 238375) ("Wilsons Advisory") whose name appears in this research certifies that (1) the recommendations and opinions expressed in this research accurately reflect the analyst's personal, independent and objective views about any and all of the subject securities or issuers; (2) no part of the analyst's compensation was, is, or will be, directly or indirectly, related to the specific recommendations or views expressed by the analyst in the research; and (3) to the best of the analyst's knowledge, he/she is not in receipt of material non-public information about the issuer.

| Disclaimer

This document has been prepared by Wilsons Advisory. This communication is not to be disclosed in whole or part or used by any other party without Wilsons Advisory's prior written consent. All material presented in this document, unless specifically indicated otherwise, is under copyright to Wilsons Advisory. None of the material, its content, nor any copy of it, may be altered in any way, transmitted to, copied or distributed to any other party, without the prior express written permission of Wilsons Advisory. This document is not directed to, or intended for distribution to or use by, any person or entity who is a citizen or resident of or located in any locality, state, country or other jurisdiction where such distribution, publication, availability or use would be contrary to law or regulation or which would subject Wilsons Advisory to any registration or licensing requirement within such jurisdiction.

This document is being supplied to you solely for your information and no action should be taken on the basis of or in reliance on this document. To the extent that any information prepared by Wilsons Advisory contains any financial product advice, it is general advice only and has been prepared by Wilsons Advisory without reference to your objectives, financial situation or needs. You should consider the appropriateness of the advice in light of your own objectives, financial situation and needs before following or relying on the advice. You should also obtain a copy of, and consider, any relevant disclosure document before making any decision to acquire a financial product. Please refer to Wilsons Advisory's Financial Services Guide for more information: wilsonsadvisory.com.au/disclosures. Any person, before acting on any advice contained within this communication, should first consult with a Wilsons Advisory investment adviser to assess whether the advice within this communication is appropriate for their objectives, financial situation and needs. Those acting upon such information without advice do so entirely at their own risk.

This document provided by Wilsons Advisory is current as at the date of the issue but may be superseded by future publications. Wilsons Advisory assumes no obligation to update the information or advise on further developments relating to the company or companies covered in this document ("Companies") or relevant financial products. Wilsons Advisory has not independently verified all of the information given in this document which is provided at a point in time and may not contain all necessary information about the Companies. Wilsons Advisory makes no warranty, express or implied, concerning any information prepared by Wilsons Advisory. Wilsons Advisory expressly disclaims (1) any implied warranty of merchantability or

  1. fitness for a particular purpose, including any warranty for the use or the results of the use of any information prepared by Wilsons Advisory with respect to their correctness, quality, accuracy, completeness, reliability, performance, timeliness, or continued availability. Wilsons Advisory's research content should be viewed as an additional investment resource, not as your sole source of information. To the fullest extent permitted by law Wilsons Advisory, its related bodies corporate and their respective officers, directors, employees or agents, disclaim any and all liabilities for any loss or damage howsoever arising in connection with the use of this document or its contents. Past performance does not necessarily indicate a financial product's likely future performance.

This document may contain "forward-looking statements". Forward-looking statements, opinions and estimates provided in this document are based on assumptions and contingencies which are outside the control of Wilsons Advisory and are subject to change without notice (including but not limited to economic conditions, market volatility and company-specific fundamentals), and therefore may not be realised in the future.

This report does not constitute an offer or invitation to purchase any securities and should not be relied upon in connection with any contract or commitment whatsoever.

Wilsons Equity Research

Page 2

5 March 2024

Healthcare

Immutep Limited

Disclaimers and Disclosures

| Regulatory disclosure

Wilsons Advisory restricts research analysts from trading in securities for which they write research. Other Wilsons Advisory employees may hold interests in the company, but none of those interests are material. Wilsons Advisory further advises that at the date of this report, neither Wilsons Advisory and Stockbroking Limited or Wilsons Corporate Finance Limited have any material interests in the company. Wilsons Corporate Finance Limited ACN 057 547 323, AFSL 238 383 acted as Joint Lead Manager and underwriter in the May 2023 pro rata accelerated non-renounceable entitlement offer and Institutional Placement of Immutep Limited Securities for which it received fees or will receive fees for acting in this capacity.

Wilsons Advisory and Stockbroking Limited may have a conflict of interest which investors should consider before making an investment decision. Wilsons Advisory and Stockbroking Limited, Wilsons Corporate Finance Limited and its related bodies corporate trades or may trade as principal in the securities that are subject of the research report. Wilsons Advisory further advises that at the date of this report, neither Wilsons Advisory and Stockbroking Limited or Wilsons Corporate Finance Limited have any material interests in the company. Wilsons Advisory restricts research analysts from trading in securities for which they write research. Other Wilsons Advisory employees may hold interests in the company, but none of those interests are material.

| Wilsons Advisory contact

For more information please phone: 1300 655 015 or email: publications@wilsonsadvisory.com.au

Wilsons Equity Research

Page 3

Attachments

Disclaimer

Immutep Ltd. published this content on 05 March 2024 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 05 March 2024 16:02:07 UTC.