Item 1.01. Entry into a Material Definitive Agreement

On March 6, 2022, we signed the Share Exchange Agreement, as amended. For a description of the Share Exchange, and the material agreements entered into therewith, please see Item 2.01 of this Current Report on Form 8-K, which disclosure is incorporated herein by reference.

Item 2.01. Completion of Acquisition or Disposition of Assets

SHARE EXCHANGE AGREEMENT AND SHARE EXCHANGE BETWEEN MANUKA LTD AND ARTEMIS THERAPEUTICS INC.

On March 6, 2022, we signed our Share Exchange Agreement between Artemis and the Manuka, pursuant to which Manuka will become Artemis' wholly owned subsidiary. Since its inception, Manuka's business activities primarily consisted of distributing M?nuka honey imported from New Zealand, developing and distributing supplements aimed at the beauty and skincare markets and, developing and manufacturing skincare products based on New Zealand's M?nuka honey and bee venom, among other natural ingredients. All three segments of Manuka's products are to be marketed and sold solely on its websites. Manuka's skincare products are manufactured in Israel.

The Share Exchange Agreement provides that, upon the terms, and subject to the conditions set forth therein, on the closing date, which occurred on June 30, 2022 (the "Closing"), Artemis acquired all of the outstanding shares of Manuka (the "Manuka Shares") from Manuka's shareholders in exchange for an aggregate amount of 33,791,641 shares of common stock of Artemis and 110,000 shares of Artemis' Series D Preferred stock (convertible into 66,000,000 shares of Artemis' common stock) (collectively, the "Consideration Shares"), such that Manuka's shareholders hold, immediately following the Closing, eighty-nine percent (89%) of Artemis' issued and outstanding share capital (including and assuming the full conversion of the Series D Preferred stock). At Closing, and as required as a condition by the Israeli Tax Authority to affect a tax ruling to approve the transactions contemplated by the Share Exchange Agreement, which was received on June 21, 2022 (the "Tax Ruling"), the Manuka Shares and the Consideration Shares will be placed in escrow with a third-party escrow agent. As required under Israeli law, following the Closing, and upon receipt of regulatory approvals, Manuka will become Artemis' wholly owned subsidiary. This transaction was exempt from registration under Section 4(a)(2) of the Securities Act as not involving any public offering. None of the securities were sold through an underwriter and, accordingly, there were no underwriting discounts or commissions involved.

Following the Closing, (i) the Manuka Shares have been released to Artemis, and (ii) the Consideration Shares have been released to the Shareholders. As required pursuant to the Tax Ruling, prior to the Closing, the parties have engaged a trustee (the "103K Trustee") under a separate trust agreement (the "Trust Agreement"), who shall hold in trust (a) all Manuka Shares for the benefit of Artemis, and (b) all Consideration Shares for the benefit of Shareholders, with the foregoing being respectively released to the designated beneficiary pursuant to the terms of the Trust Agreement and the Tax Ruling.

The Share Exchange Agreement contains customary representations and warranties from each party to the agreement, and each party has agreed to customary covenants, including, among others, covenants relating to (x) the conduct of each of Manuka's and Artemis' business during the period between the execution of the Share Exchange Agreement and the Closing, and (y) no transfer of Manuka Shares by the Shareholders during the period between the execution of the Share Exchange Agreement and the Closing. The Share Exchange Agreement contains mutual indemnification provisions. The First Amendment included registration rights for the Company's shareholders, to be registered within 90 days from the Closing and . . .

Item 2.02. Results of Operations and Financial Condition.



                    MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                 FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following Management's Discussion and Analysis of Financial Condition and Results of Operations ("MD&A") covers information pertaining to the Company for the three months ended March 31, 2022 and the year ended December 31, 2021 and should be read in conjunction with the unaudited interim consolidated condensed financial statements for the three months ended March 31, 2022 and related notes and with the consolidated audited financial statements and related notes of the Company as of and for the year ended December 31, 2021 and related notes thereto. Except as otherwise noted, the financial information contained in this MD&A and in the financial statements has been prepared in accordance with accounting principles generally accepted in the United States of America. All amounts are expressed in U.S. dollars unless otherwise noted. This discussion contains forward-looking statements that involve risks and uncertainties. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of certain factors.

Overview

We are a beauty company that develops and distributes premium-quality skincare products, that are based on M?nuka honey and bee venom. Since our inception, Manuka's business activities primarily consisted of developing and manufacturing skincare products based on M?nuka honey and bee venom from New Zealand, among other natural ingredients, marketed and sold solely on our website in Israel, www.bmanuka.co.il, and to be marketed and sold globally at www.bmanuka.com.

Components of Operating Results

Operating Expenses

Our current operating expenses consist of two components - sales and marketing and general and administrative expenses.

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Sales and Marketing Expenses

Our Sales and Marketing Expenses consist primarily of Advertising expenses and public relations to promote the sales of the company's products. Our sales and marketing expenses totaled $67 thousand representing an increase of $29 thousand, or 73%, compared to $38 thousand for the year ended December 31, 2020. The increase was primarily attributable to an increase of $29 thousand in the company effort to touch the market target and in order to increase the exposure to the company's products among its customers. The following table discloses the breakdown of sales and marketing expenses:

Comparison of the Three Months Ended March 31, 2022 to the Three Months Ended March 31, 2021

Results of Operations

The following table presents our results of operations for the three months ended March 31, 2022 and 2021.



                                                     For the Three Months Ended
                                                              March 31,
                                                      2022                2021
                                                           (in thousands)
Sales and marketing expenses, net                 $         109       $          10
General and administrative expenses                         102                  21
Operating loss                                             (198 )               (31 )
Financial expenses                                           (5 )                (2 )
Net loss                                          $        (203 )     $         (33 )
. . .

Item 3.02. Unregistered Sales of Equity Securities

Shares Issued in Connection with the Share Exchange Agreement

On June 30, 2022, pursuant to the terms of the First Amendment to the Share Exchange Agreement, all the Ordinary Shares of Manuka Ltd. were exchanged for an amount of 31,549,132 shares of common stock of Artemis and 110,000 shares of Series D Preferred stock (convertible into 66,000,000 shares of Artemis' common stock) . This transaction was exempt from registration under Section 4(a)(2) of the Securities Act as not involving any public offering. None of the securities were sold through an underwriter and, accordingly, there were no underwriting discounts or commissions involved.

Following the Closing, (i) the Manuka Shares have been released to Artemis, and (ii) the Consideration Shares have been released to the Shareholders. As required pursuant to the Tax Ruling, prior to the Closing, the parties have engaged the 103K Trustee under a separate Trust Agreement, who shall hold in trust (a) all Manuka Shares for the benefit of Artemis, and (b) all Consideration Shares for the benefit of Shareholders, with the foregoing being respectively released to the designated beneficiary pursuant to the terms of the Trust Agreement and the Tax Ruling.

The Share Exchange Agreement contains customary representations and warranties from each party to the agreement, and each party has agreed to customary covenants, including, among others, covenants relating to (x) the conduct of each of Manuka's and Artemis' business during the period between the execution of the Share Exchange Agreement and the Closing, and (y) no transfer of Manuka Shares by the Shareholders during the period between the execution of the Share Exchange Agreement and the Closing. The Share Exchange Agreement contains mutual indemnification provisions.

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The Share Exchange Agreement and the First Amendment are each filed as an exhibit to this report. All descriptions of the Share Exchange Agreement herein are qualified in their entirety by reference to the text thereof filed as an exhibit hereto, which is incorporated herein by reference.

In addition, on June 30, 2022, Artemis entered into various debt forgiveness agreements with various existing stockholders, including Tonak Ltd., for the forgiveness of an aggregate of $306,117 in outstanding debt in exchange for the issuance of 3,031,567 shares of Artemis' common stock. On June 30, 2022, Artemis entered into various warrant exchange agreements for the exchange of certain warrants to purchase shares of Artemis' common stock, originally issued in October 2017, in exchange for an aggregate of 2,342,802 shares of Artemis' common stock. Finally, on June 30, 2022, Artemis entered into a debt forgiveness agreement and warrant exchange agreement with Cutter Mill Capital, pursuant to which Artemis agreed to issue 894,169 shares of Artemis' common stock. Artemis also agreed to register all such shares issued to Cutter Mill Capital, including any and all shares issued or issuable to such holder upon conversion of any of its outstanding preferred stock, within the earlier of 60 days following the date hereof (provided, however that in the event the company has not cleared comments with the SEC with respect to this filing relating to the transactions contemplated by the Share Exchange Agreement, such date shall be 90 days following the date if the agreement) and the date that Artemis files its next registration statement, and agreed to obtain effectiveness within 90 days (or . . .

Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain

Officers, Compensatory Arrangements of Certain Officers

The disclosures set forth in Item 2.01 are hereby incorporated by reference into this Item 5.02.

Item 5.06. Change in Shell Company Status

Following the consummation of the Share Exchange described in Item 1.01 and Item 2.01 of this Current Report on Form 8-K, the Company believes that it is not a shell corporation as that term is defined in Rule 405 of the Securities Act and Rule 12b-2 of the Exchange Act.

Item 9.01. Financial Statements and Exhibits

(a) Financial Statements of Business Acquired.

The audited financial statements of Manuka for the years ended December 31, 2021 and December 31, 2020 and the unaudited financial statements of Manuka for the interim period as of March 31, 2022 are filed herewith as Exhibit 99.1, respectively, and are incorporated herein by reference.

(b) Pro Forma Financials

The unaudited pro forma balance sheet and statement of operations of the Company and Manuka, and the notes thereto as of March 31, 2022 are filed herewith as Exhibit 99.2 and 99.3 hereto and are incorporated herein by reference.

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  (d) Exhibits



  3.1*         Articles of Incorporation of the Company, as amended (previously filed
             as exhibit 3.1 to our Form 10-SB filed with the SEC on June 10, 1998;
             Exhibits 3.1 and 3.2 to our Current Report on Form 8-K filed with the SEC
             on November 8, 2002; Exhibit 4 to our Current Report on Form 8-K filed
             with the SEC on July 22, 2003; and Exhibit 3.1 to our Current Report on
             Form 8-K filed with the SEC on September 24, 2010).
  4.1**        Certificate of Designation of Series D Convertible Preferred Stock.
  10.1*        Share Exchange Agreement by and between Artemis Therapeutics, Inc.,
             Manuka Ltd., an Israeli company and the shareholders of Manuka Ltd.,
             dated March 6, 2022 (previously filed as exhibit 10.1 to our Form 10-Q
             with the SEC on May 23, 2022).
  10.2**^      First Amendment to the Share Exchange Agreement by and between Artemis
             Therapeutics, Inc., Manuka Ltd., an Israeli company and the shareholders
             of Manuka Ltd., dated June 30, 2022.
  10.3**^      Supply Agreement between Manuka Ltd. and Waitemata Honey Co. Ltd.,
             dated July 20, 2021.
  10.4**^      English Translation of Agreement between Manuka Ltd. and Chic Cosmetic
             Industries 1987 Ltd., dated December 14, 2021.
  10.5**       English Translation of Import License from the Israeli Ministry of
             Health, dated February 28, 2022.
  10.6**       Form of Warrant Exchange Agreement.
  10.7**       Form of Debt Forgiveness Agreement.
  21.1**       List of Subsidiaries.
  99.1**       Audited Financial Statements of Manuka Ltd. for the years ended
             December 31, 2021 and December 31, 2020.
  99.2**       Unaudited Financial Statements of Manuka Ltd. as of March 31 ,2022.
  99.3**       Unaudited Pro Forma Balance Sheet and Statement of Operations of
             Artemis Therapeutics, Inc. and Manuka Ltd. as of March 31, 2022
104          Cover Page Interactive Data File (formatted as Inline XBRL and contained
             in Exhibit 101).

^            Certain identified information in the exhibit has been excluded from the
             exhibit because it is both (i) not material and (ii) would likely cause
             competitive harm to the Company if publicly disclosed. The Company agrees
             to furnish supplementally a copy of any omitted schedule or exhibit to the
             SEC upon request.
*            Previously filed.
**           Filed herewith.



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