ARTEMIS THERAPEUTICS, INC. : Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits (form 8-K)

Item 1.01. Entry into a Material Definitive Agreement.

On November 4, 2021, Artemis Therapeutics, Inc. (the "Company") issued two unsecured promissory notes (each, a "Note" and collectively the "Notes") in the aggregate principal amount of $60,000, with original issuance dates of September 19, 2021 and August 15, 2021. In that regard, one Note, with a principal aggregate balance of $30,000, was issued to KNRY Ltd., an entity related to Nadav Kidron, the natural person with voting and dispositive power over the securities held by Tonak Ltd., the Company's largest shareholder. In addition, one Note, with an aggregate principal balance of $30,000, was issued to Harmony (H.A.) Investments Ltd. Each Note accrues interest at a rate of 10% per annum until the Note is repaid in full. All payments of principal, interest and other amounts under each Note are payable by December 19, 2021. The proceeds of the Notes will be used by the Company for general working capital purposes.

Item 2.03. Creation of a Direct Financial Obligation or an Obligation Under an Off-Balance Sheet Arrangement of the Registrant.

The information included in Item 1.01 of this Current Report on Form 8-K is hereby incorporated by reference into this Item 2.03.

Item 9.01. Financial Statements and Exhibits.

(d) Exhibits

Exhibit Number Exhibit Description

Exhibit 104 Cover Page Interactive Data File - the cover page XBRL tags are embedded

            within the Inline XBRL document.

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