On December 13, 2021, Medicine Man Technologies, Inc. received written notice of the resignation of Pratap Mukharji as a member of the Company’s board of directors. Mr. Mukharji was Chairman of the board of directors’ Audit Committee and Nominating and Governance Committee. Mr. Mukharji’s resignation is not the result of any disagreement with the Company on any matters relating to the Company’s operations, policies, or practices. On December 13, 2021, the Company’s board of directors appointed Nirup Krishnamurthy, the Company’s Chief Operating Officer, as a Class B director to fill the vacancy left by Mr. Mukharji and Jonathan Berger as a Class A director to fill an existing vacancy. The Company expects that its board of directors will appoint Mr. Berger to the board of director’s Audit Committee. Mr. Krishnamurthy will serve until his term expires at the Company’s 2023 annual meeting of stockholders and until a successor is elected and qualified, or until his earlier death, resignation or removal. Mr. Berger will serve until his term expires at the Company’s 2022 annual meeting of stockholders and until a successor is elected and qualified, or until his earlier death, resignation or removal.