NanoString Technologies, Inc. announced the release of the first public dataset of the whole transcriptome obtained at true single-cell resolution on the CosMx? Spatial Molecular Imager (SMI). The data will be highlighted at the 42nd annual J.P. Morgan Healthcare Conference 2024 in San Francisco during NanoString?s corporate presentation on January 10, 2024, at 5:15 pm ET.

CosMx Whole Transcriptome Panel Achieves Scientific Moonshot: NanoString is the first company to achieve the scientific breakthrough of providing true single-cell whole transcriptome imaging. This technological milestone was accomplished using the CosMx SMI platform allowing researchers to simultaneously visualize the expression of every protein-coding gene in the human genome in situ, providing the ultimate capability for single cell spatial biology. The CosMx Whole Transcriptome Panel transforms the potential to extract biological insights from formalin-fixed paraffin-embedded (FFPE) tissue samples.

By imaging the expression of almost 19,000 genes at once, this product will provide almost 40x the coverage of assays currently marketed by competing platforms. Researchers can now explore millions of cells per experiment, identify rare cell types, and understand cell-to-cell interactions in spatial context, providing a comprehensive understanding of cellular landscapes that has never before been accessible. These capabilities will be available at lower cost per single cell while providing higher cellular throughput than traditional single cell RNA sequencing (scRNA-seq). NanoString plans to commercially launch the CosMx Whole Transcriptome Panel in 2025.

NanoString is marking this milestone achievement with the public release of a whole transcriptome CosMx SMI dataset generated from FFPE samples of healthy human pancreas tissue. This first-of-its-kind dataset demonstrates the functional biology of the pancreas revealing rare cell types that are typically lost with traditional scRNA-seq methods. This dataset was generated using a prototype version of the panel and related software, and the performance of the new capability is expected to improve in the full commercial version, becoming even more impressive over time.

Anticipating intense interest from the scientific community, NanoString will feature the Whole Transcriptome capabilities of CosMx SMI during presentations at the upcoming AGBT meeting in Orlando, Florida, Feb. 5-8, 2024. Customers who have gained access to prototypes of the CosMx Whole Transcriptome Panel will present datasets generated on pancreatic cancer, colorectal cancer, and human brain.

NanoString also remains on track to begin commercial shipment of the CosMx Human 6K Discovery Panel beginning in First Quarter 2024. This innovative panel, offering 6x higher plex than current CosMx SMI panels, will empower researchers to delve deeper into cell states and function, explore intricate cell-to-cell interactions, and deliver new insights into spatial cellular responses at an unprecedented level.