Oncolytics Biotech Inc. announced the poster presentation of positive, updated results from the Phase 1/2 GOBLET study evaluating pelareorep-based combination therapy in patients with pancreatic ductal adenocarcinoma (PDAC) at the European Society for Medical Oncology meeting (ESMO 2023), taking place in Madrid, Spain. Summary of Data and Findings from the PDAC Arm of the Phase 1/2 GOBLET Study: Tumor Responses: Consistent with the abstract, data from the study outlined patient responses, including: Objective Response Rate (ORR) of 62% (54% confirmed by two or more scans); A Disease Control Rate (DCR) of 85%. Survival data: Evaluated based on 4 parameters including: Median duration of response was 5.7 months; Median progression-free survival (PFS) was 7.2 months; Interim 12-month survival rate was 46%; Interim median overall survival (OS) was 10.6 months.

T-Cell Populations: Analysis of changes of T-cell clones and tumor-infiltrating lymphocytes (TILs) showed: Mean baseline TIL cell levels of 22%; Expansion of pre-existing and new T cell clones, including the expansion of TIL-specific clones; A correlation between in the expansion in the blood of TIL-specific clones and tumor response. Safety: The treatment combination has been well tolerated with no safety concerns; Most common grade 3 and 4 treatment-related adverse events were related to red and white blood cell counts (anemia, neutropenia and decreased neutrophil counts).