Oncotelic Therapeutics, Inc. announced it presented new clinical confirming TGF-ß2 as the appropriate target for gliomas at the 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research- Translating Knowledge into Practice December 10 - 14, 2022, Maui, Hawaii. TGF- ß consists of three highly similar isoforms: ß1, ß2, ß3; Retrospective analysis TCGA database demonstrated that high TGF-ß2, but not TGF-ß1 nor TGF-ß3, is prognostic indicator for worse OS. Reduced TGF-ß2 in Pediatric Brainstem Patients increased OS from 9 mos to 22 mos, N=95 pts, p<0.0001.

Reduced TGF-ß2 in Gliomas patients treated with TMZ increased OS from 25 mos to 94 mos, N=230 pts, p<0.0001. Reduced TGF-ß2 in Gliomas patients treated with Radiation increased OS from 25 mos to 94 mos, N=293 pts, p<0.0001.