Oxford Immunotec Global PLC announced an update to the configuration of the T-SPOT Discovery SARS-CoV-2 kit. The kit, for research use only, has been updated using the Company’s growing expertise of the T cell response to SARS-CoV-2 infection. The previous T-SPOT Discovery SARS-CoV-2 kit configuration included five antigen wells, each containing a mix of peptides representing target epitopes derived from the virus, with areas of high homology to endemic coronaviruses removed. Using the Company’s growing results database, it has been possible to make improvements to the configuration of the kit. The new configuration includes only antigens that, in studies, have shown to induce robust T cell responses specific to SARS-CoV-2. They are designed as overlapping peptides to maximise the detection of the breadth of the human immune response in a genetically unrestricted manner. An additional panel has been included containing epitopes of high genetic homology to endemic human coronaviruses (HCoV). This panel will facilitate research into the role HCoV play in the immune response to SARS-CoV-2 infection. There is an increasing body of evidence suggesting that previous exposure to HCoV may contribute to the immune response to infection by SARS-CoV-2 in some individuals. A recent report on health care workers in the US demonstrated cross-reactive T cell responses between HCoV and SARS-CoV-2 infections1. The article suggested that HCoV cross-reactivity could be protective against SARS-CoV-2 infection. The inclusion of a cross-reactive panel in the T-SPOT Discovery SARS-CoV-2 kit will help investigators understand this effect in more detail and better understand the broader immune responses.