REGEN BIOPHARMA, INC. Regen BioPharma Inc. had previously discussed initiation of a series of experiments to validate its DuraCAR CAR-T cell therapeutic. The first phase of in vitro experiments successfully synthesized and expressed in transfected cells the chimeric antigen receptor (CAR) construct targeting CD19 and NR2F6. However, a second set of experiments yielded unexpected results whereby siRNAs designed to suppress NR2F6 mRNA expression yielded the opposite result.
The company has engaged a contract research organization (CRO) that is independent of the CRO which performed the second set of experiments to determine if these surprising findings are reproducible. If confirmed, these results could lead to the development of a therapy whereby T-Cells that suppress autoimmunity can be created.
