New clinical data has demonstrated the potential of a one-time gene therapy for vision loss.
The two-year data showed that ABBV-RGX-314 provided stable or improved visual acuity and retinal thickness in patients. Stable or improved vision and retinal anatomy was observed up to two years. Most of the participants were found to require only a few or no supplemental anti-VEGF injections during this period,
About the gene therapy ABBV-RGX-314
long-term data has shown that the gene therapy was well-tolerated and facilitated stable or improved vision up to four years”
Developed in collaboration with AbbVie, ABBV-RGX-314 comprises of the NAV® AAV8 vector.
Additional long-term data has shown that the gene therapy was well-tolerated and facilitated stable or improved vision up to four years.
Importance of the findings
Based on these data, subject to regulatory approval, a one-time dose of the gene therapy could provide a novel therapy option for patients with wet AMD. The disease is currently managed through frequent anti-VEGF injections, which is a burden for these patients,
A single administration of the gene therapy ABBV-RGX-314 could potentially provide long-lasting treatment outcomes [for wet AMD], according to Dr
“ABBV-RGX-314 [could] become a first-in-class gene therapy for wet AMD and the standard of care to treat and prevent progression of diabetic retinopathy,” stated
Regulatory submissions are expected in late 2025 through the first half of 2026,
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