First Quarter 2024 Financial Highlights
- Revenue grew 13% year-over-year to
$15.8 million ; Constant currency revenue excluding COVID-related revenue grew 12% year-over-year - Gross margins were 65.9% on a reported basis and 70.5% on an adjusted basis
- Operating loss was
$18.8 million on a reported basis and$14.1 million on an adjusted basis, representing year-over-year improvements of 3% and 13%, respectively - Reiterated full-year guidance, including revenue growth of 25% to 30%, adjusted gross margin of 72.5% to 72.7%, and adjusted operating loss between
$45 million and$50 million - Entered into an agreement with
Perceptive Advisors for up to$50 million in debt financing to provide additional capital flexibility to accelerate our growth and buttress our already strong balance sheet
"We delivered solid achievements in Q1 to fuel future growth, including the signing of 27 new core genomics customers, the official launch of MSK-ACCESS® powered with SOPHiA DDM™, which has already gained remarkable traction worldwide, and new milestones working with BioPharma partners to diversify and expand the SOPHiA DDM™ network into locations such as
Camblong added, "Looking forward to the rest of 2024, our team will remain laser-focused on onboarding the influx of new customers who have adopted SOPHiA DDM™ over the past two quarters, while also continuing to build off of the significant momentum of our new Liquid Biopsy offering with the launch of MSK-ACCESS® powered with SOPHiA DDM™.”
Business Highlights
Expanding usage of SOPHiA DDM™ worldwide
- Reached 463 core genomics customers as of
March 31, 2024 , who use SOPHiA DDM™ regularly to analyze cases of cancer and rare disease, up from 437 customers at the end of Q1 2023 - Performed approximately 84,000 analyses on SOPHiA DDM™ in Q1 2024, representing 9% year-over-year analysis volume growth or 11% growth when excluding COVID-related analyses
- Officially launched the Liquid Biopsy application, MSK-ACCESS® powered with SOPHiA DDM™, at the end of April; Capitalized on strong market demand and signed 9 customers pre-launch
Accelerating adoption of SOPHiA DDM™ by landing new Clinical customers
- Landed 27 new core genomic customers in Q1 2024 who will implement SOPHiA DDM™ over the next several months, representing the second consecutive quarter of strong new business growth
- Continued building momentum in the U.S. market with 34% year-over-year analysis volume growth in Q1 2024, 27% year-over-year revenue growth, and the signing of major, new
U.S. healthcare institutions such asMayo Clinic , one of the top-ranked academic medical centers in the world, who is adopting SOPHIA DDM™’s capabilities in Oncology starting with HemOnc applications - Added 3 new countries to the SOPHiA DDM™ network with the signing of new customers in
Romania ,Norway , andNigeria - Signed our first SOPHiA DDM™ customer in
Africa , with the addition of Syndicate Bio, a precision medicine lab inNigeria that aims to provide cancer diagnosis and treatment to the over 1 million cancer patients inAfrica each year; Syndicate Bio is the first lab inAfrica to adopt MSK-ACCESS® powered with SOPHiA DDM™ as part of our monumental collaboration with MSK and AstraZeneca, which aims to advance health equity on a global scale by expanding access to comprehensive cancer testing - Continued gaining traction with the U.K.’s National Health Service (“NHS”) with the signing of Synnovis, a
London -based lab providing services to theNHS , who will be adopting SOPHiA DDM™’s new Liquid Biopsy applications
Leveraging SOPHiA DDM™ to deliver value to BioPharma partners
- Finalized agreement with AstraZeneca to sponsor the deployment of MSK-ACCESS® powered with SOPHiA DDM™ to numerous institutions across the globe in 2024
- Signed our first ever Breast Cancer Pilot project leveraging SOPHiA DDM™’s multimodal algorithms and factories to identify predictive signatures of response to therapy which could lead to better, more personalized treatment of patients with advanced hormone-positive breast cancer
Growing sustainably by maintaining an obsession on operational excellence
- Remained laser-focused on operational excellence by improving adjusted operating loss 13% year-over-year in Q1 2024 and maintaining adjusted gross margin above 70%
- Reaffirmed commitment to grow sustainably and achieve adjusted operating profitability in the next 2+ years
Strengthening our capital position to support future growth initiatives
- Entered into a new, five-year senior secured credit facility with
Perceptive Advisors onMay 2, 2024 ; the agreement provides access of up to$50 million in debt financing, consisting of an initial tranche of$15 million , and an additional tranche of$35 million available for draw throughMarch 2026 - Interest is payable in cash on the outstanding principal amount at a per annual rate equal to the sum of the higher of the applicable secured overnight financing rate (“SOFR”) or the minimum floor rate of 4.00% plus 6.25%
- Under the terms of the agreement, Perceptive has been issued warrants to purchase 400,000 shares of the Company’s stock as of the closing date, with an exercise price equal to the 10-day volume weighted average price (“VWAP”) preceding the closing date. Warrants to purchase 200,000 shares will be issued immediately, and warrants to purchase an additional 200,000 will be issued upon drawing of the subsequent tranche
2024 Financial Outlook
Based on information as of today,
- Revenue between
$78 million and$81 million , representing growth of 25% to 30% compared to full year 2023 revenue - Adjusted gross margin between 72.5% and 72.7%, compared to 72.2% in FY 2023
- Adjusted operating loss between
$45 million and$50 million , compared to$55.9 million in FY 2023
Other than with respect to revenue, the Company only provides guidance on a non-IFRS basis. The Company does not provide a reconciliation of forward-looking adjusted gross margin (non-IFRS measure) to gross margin (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses that are necessary for such reconciliation. In addition, the Company does not provide a reconciliation of forward-looking adjusted operating loss (non-IFRS measure) to operating loss (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses and intangible assets, share-based compensation expenses, and non-cash portion of pensions paid in excess of actual contributions, that are necessary for such reconciliation.
Earnings Call and Webcast Information
Non-IFRS Financial Measures
To provide investors with additional information regarding the company’s financial results,
- Adjusted gross profit, which the company calculates as revenue minus cost of revenue adjusted to exclude amortization of capitalized research and development expenses;
- Adjusted gross profit margin, which the company calculates as adjusted gross profit as a percentage of revenue;
- Adjusted operating loss, which the company calculates as operating loss adjusted to exclude amortization of capitalized research and development expenses, amortization of intangible assets, share-based compensation expense, and non-cash portion of pensions expense paid in excess of actual contributions to match the actuarial expense.
These non-IFRS measures are key measures used by
These non-IFRS measures have limitations as financial measures, and you should not consider them in isolation or as a substitute for analysis of SOPHiA GENETICS’ results as reported under IFRS. Some of these limitations are:
- These non-IFRS measures exclude the impact of amortization of capitalized research and development expenses and intangible assets. Although amortization is a non-cash charge, the assets being amortized may need to be replaced in the future and these non-IFRS measures do not reflect capital expenditure requirements for such replacements or for new capital expenditures;
- These non-IFRS measures exclude the impact of share-based compensation expenses. Share-based compensation has been, and will continue to be for the foreseeable future, a recurring expense in the company’s business and an important part of its compensation strategy;
- These non-IFRS measures exclude the impact of the non-cash portion of pensions paid in excess of actual contributions to match actuarial expenses. Pension expenses have been, and will continue to be for the foreseeable future, a recurring expense in the business; and
- Other companies, including companies in the company’s industry, may calculate these non-IFRS measures differently, which reduces their usefulness as comparative measures.
Because of these limitations, you should consider these non-IFRS measures alongside other financial performance measures, including various cash flow metrics, net income and other IFRS results.
The tables below provide the reconciliation of the most comparable IFRS measures to the non-IFRS measures for the periods presented.
Presentation of Constant Currency Revenue and Excluding COVID-19-Related Revenue
The company’s management and board of directors use constant currency revenue growth to evaluate growth and generate future operating plans. The exclusion of the impact of exchange rate fluctuations provides comparability across reporting periods and reflects the effects of customer acquisition efforts and land-and-expand strategy. Accordingly, it believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating revenue growth in the same manner as the management and board of directors. However, this non-IFRS measure has limitations, particularly as the exchange rate effects that are eliminated could constitute a significant element of its revenue and could significantly impact performance and prospects. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.
In addition to constant currency revenue, the company presents constant currency revenue excluding COVID-19-related revenue to further remove the effects of revenues that are derived from sales of COVID-19-related offerings, including a NGS assay for COVID-19 that leverages the SOPHiA DDM™ Platform and related products and solutions analytical capabilities and COVID-19 bundled access products.
The table below provides the reconciliation of the most comparable IFRS growth measures to the non-IFRS growth measures for the current period.
About
Forward-Looking Statements
This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding
Interim Condensed Consolidated Statements of Loss (Amounts in USD thousands, except per share data) (Unaudited) | |||||||
Three months ended | |||||||
2024 | 2023 | ||||||
Revenue | $ | 15,779 | $ | 13,966 | |||
Cost of revenue | (5,374 | ) | (4,272 | ) | |||
Gross profit | 10,405 | 9,694 | |||||
Research and development costs | (9,391 | ) | (9,334 | ) | |||
Selling and marketing costs | (6,951 | ) | (6,424 | ) | |||
General and administrative costs | (12,825 | ) | (13,242 | ) | |||
Other operating income, net | 6 | 19 | |||||
Operating loss | (18,756 | ) | (19,287 | ) | |||
Interest income, net | 758 | 862 | |||||
Foreign exchange gains (losses) | 4,610 | (1,168 | ) | ||||
Loss before income taxes | (13,388 | ) | (19,593 | ) | |||
Income tax expense | (316 | ) | (107 | ) | |||
Loss for the period | (13,704 | ) | (19,700 | ) | |||
Attributable to the owners of the parent | (13,704 | ) | (19,700 | ) | |||
Basic and diluted loss per share | $ | (0.21 | ) | $ | (0.31 | ) |
Interim Condensed Consolidated Statements of Comprehensive Loss (Amounts in USD thousands) (Unaudited) | |||||||
Three months ended | |||||||
2024 | 2023 | ||||||
Loss for the period | $ | (13,704 | ) | $ | (19,700 | ) | |
Other comprehensive (loss) income: | |||||||
Items that may be reclassified to statement of loss (net of tax) | |||||||
Currency translation differences | (9,393 | ) | 1,971 | ||||
Total items that may be reclassified to statement of loss | (9,393 | ) | 1,971 | ||||
Items that will not be reclassified to statement of loss (net of tax) | |||||||
Remeasurement of defined benefit plans | (15 | ) | (70 | ) | |||
Total items that will not be reclassified to statement of loss | (15 | ) | (70 | ) | |||
Other comprehensive (loss) income for the period | $ | (9,408 | ) | $ | 1,901 | ||
Total comprehensive loss for the period | $ | (23,112 | ) | $ | (17,799 | ) | |
Attributable to owners of the parent | $ | (23,112 | ) | $ | (17,799 | ) |
Interim Condensed Consolidated Balance Sheets (Amounts in USD thousands) (Unaudited) | |||||||
Assets | |||||||
Current assets | |||||||
Cash and cash equivalents | $ | 103,735 | $ | 123,251 | |||
Accounts receivable | 10,890 | 13,557 | |||||
Inventory | 6,016 | 6,482 | |||||
Prepaids and other current assets | 4,486 | 4,757 | |||||
Total current assets | 125,127 | 148,047 | |||||
Non-current assets | |||||||
Property and equipment | 6,583 | 7,469 | |||||
Intangible assets | 26,294 | 27,185 | |||||
Right-of-use assets | 14,714 | 15,635 | |||||
Deferred tax assets | 1,716 | 1,720 | |||||
Other non-current assets | 5,824 | 6,100 | |||||
Total non-current assets | 55,131 | 58,109 | |||||
Total assets | $ | 180,258 | $ | 206,156 | |||
Liabilities and equity | |||||||
Current liabilities | |||||||
Accounts payable | $ | 6,245 | $ | 5,391 | |||
Accrued expenses | 12,908 | 17,808 | |||||
Deferred contract revenue | 8,336 | 9,494 | |||||
Lease liabilities, current portion | 2,704 | 2,928 | |||||
Total current liabilities | 30,193 | 35,621 | |||||
Non-current liabilities | |||||||
Lease liabilities, net of current portion | 14,738 | 15,673 | |||||
Defined benefit pension liabilities | 2,971 | 3,086 | |||||
Other non-current liabilities | 124 | 334 | |||||
Total non-current liabilities | 17,833 | 19,093 | |||||
Total liabilities | 48,026 | 54,714 | |||||
Equity | |||||||
Share capital | 4,048 | 4,048 | |||||
Share premium | 472,031 | 471,846 | |||||
(638 | ) | (646 | ) | ||||
Other reserves | 48,279 | 53,978 | |||||
Accumulated deficit | (391,488 | ) | (377,784 | ) | |||
Total equity | 132,232 | 151,442 | |||||
Total liabilities and equity | $ | 180,258 | $ | 206,156 |
Interim Condensed Consolidated Statements of Cash Flows (Amounts in USD thousands) (Unaudited) | |||||||
Three months ended | |||||||
2024 | 2023 | ||||||
Operating activities | |||||||
Loss before tax | $ | (13,388 | ) | $ | (19,593 | ) | |
Adjustments for non-monetary items | |||||||
Depreciation | 1,158 | 1,284 | |||||
Amortization | 901 | 606 | |||||
Finance (income) expense, net | (5,046 | ) | 169 | ||||
Expected credit loss allowance | (48 | ) | 638 | ||||
Share-based compensation | 3,714 | 2,430 | |||||
Movements in provisions and pensions | (135 | ) | 349 | ||||
Research tax credit | (104 | ) | (451 | ) | |||
Working capital changes | |||||||
Decrease (Increase) in accounts receivable | 2,168 | (3,169 | ) | ||||
Increase in prepaids and other assets | (182 | ) | (859 | ) | |||
Decrease in inventory | 376 | 876 | |||||
(Decrease) Increase in accounts payables, accrued expenses, deferred contract revenue, and other liabilities | (4,058 | ) | 2,062 | ||||
Cash used in operating activities | (14,644 | ) | (15,658 | ) | |||
Income tax paid | (1 | ) | (121 | ) | |||
Interest paid | (147 | ) | (5 | ) | |||
Interest received | 953 | 995 | |||||
Net cash flows used in operating activities | (13,839 | ) | (14,789 | ) | |||
Investing activities | |||||||
Purchase of property and equipment | (99 | ) | (508 | ) | |||
Acquisition of intangible assets | (50 | ) | (284 | ) | |||
Capitalized development costs | (1,809 | ) | (935 | ) | |||
Proceeds upon maturity of term deposits | — | 16,213 | |||||
Net cash flow (used in) provided from investing activities | (1,958 | ) | 14,486 | ||||
Financing activities | |||||||
Proceeds from exercise of share options | 188 | 151 | |||||
Capitalized borrowing transaction costs | (49 | ) | — | ||||
Payments of principal portion of lease liabilities | (735 | ) | (1,086 | ) | |||
Net cash flow used in financing activities | (596 | ) | (935 | ) | |||
Decrease in cash and cash equivalents | (16,393 | ) | (1,238 | ) | |||
Effect of exchange differences on cash balances | (3,123 | ) | 695 | ||||
Cash and cash equivalents at beginning of the year | 123,251 | 161,305 | |||||
Cash and cash equivalents at end of the period | $ | 103,735 | $ | 160,762 |
Reconciliation of IFRS Revenue Growth to Constant Currency Revenue Growth and Constant Currency Revenue Growth Excluding COVID-19-Related Revenue (Amounts in USD thousands, except for %) (Unaudited) | |||||||||||
Three months ended | |||||||||||
2024 | 2023 | Growth | |||||||||
IFRS revenue | $ | 15,779 | $ | 13,966 | 13 | % | |||||
Current period constant currency impact | (184 | ) | — | ||||||||
Constant currency revenue | $ | 15,595 | $ | 13,966 | 12 | % | |||||
COVID-19-related revenue | (35 | ) | (125 | ) | |||||||
Constant currency impact on COVID-19-related revenue | 2 | — | |||||||||
Constant currency revenue excluding COVID-19-related revenue | $ | 15,562 | $ | 13,841 | 12 | % |
Reconciliation of IFRS to Adjusted Gross Profit and Gross Profit Margin (Amounts in USD thousands, except percentages) (Unaudited) | |||||||
Three months ended | |||||||
2024 | 2023 | ||||||
Revenue | $ | 15,779 | $ | 13,966 | |||
Cost of revenue | (5,374 | ) | (4,272 | ) | |||
Gross profit | $ | 10,405 | $ | 9,694 | |||
Amortization of capitalized research and development expenses(1) | 727 | 432 | |||||
Adjusted gross profit | $ | 11,132 | $ | 10,126 | |||
Gross profit margin | 66 | % | 69 | % | |||
Amortization of capitalized research and development expenses(1) | 5 | % | 4 | % | |||
Adjusted gross profit margin | 71 | % | 73 | % |
Reconciliation of IFRS to Adjusted Operating Loss for the Period (Amounts in USD thousands) (Unaudited) | |||||||
Three months ended | |||||||
2024 | 2023 | ||||||
Operating loss | $ | (18,756 | ) | $ | (19,287 | ) | |
Amortization of capitalized research & development expenses(1) | 727 | 432 | |||||
Amortization of intangible assets(2) | 174 | 173 | |||||
Share-based compensation expense(3) | 3,714 | 2,430 | |||||
Non-cash pension expense(4) | 77 | 78 | |||||
Adjusted operating loss | $ | (14,064 | ) | $ | (16,174 | ) |
Reconciliation of IFRS to Adjusted Operating Loss for the fourth quarter and fiscal year 2023 (Amounts in USD thousands) (Unaudited) | |||||||
Three months ended | Year ended | ||||||
Operating loss | $ | (18,946 | ) | $ | (74,826 | ) | |
Amortization of capitalized research & development expenses(1) | 619 | 2,099 | |||||
Amortization of intangible assets(2) | 193 | 729 | |||||
Share-based compensation expense(3) | 4,211 | 15,247 | |||||
Non-cash pension expense(4) | (625 | ) | (394 | ) | |||
Costs associated with restructuring(5) | 1,232 | 1,232.00 | |||||
Adjusted operating loss | $ | (13,316 | ) | $ | (55,913 | ) |
Notes to the Reconciliation of IFRS to Adjusted Financial Measures Tables | |
(1) | Amortization of capitalized research and development expenses consists of software development costs amortized using the straight-line method over an estimated life of five years. These expenses do not have a cash impact but remain a recurring expense generated over the course of our research and development initiatives. |
(2) | Amortization of intangible assets consists of costs related to intangible assets amortized over the course of their useful lives. These expenses do not have a cash impact, but we could continue to generate such expenses through future capital investments. |
(3) | Share-based compensation expense represents the cost of equity awards issued to our directors, officers, and employees. The fair value of awards is computed at the time the award is granted and is recognized over the vesting period of the award by a charge to the income statement and a corresponding increase in other reserves within equity. These expenses do not have a cash impact but remain a recurring expense for our business and represent an important part of our overall compensation strategy. |
(4) | Non-cash pension expense consists of the amount recognized in excess of actual contributions made to our defined pension plans to match actuarial expenses calculated for IFRS purposes. The difference represents a non-cash expense but remains a recurring expense for our business as we continue to make contributions to our plans for the foreseeable future. |
(5) | Costs associated with restructuring consists of compensation paid to employees during their garden leave period, severance, and any other amounts legally owed to the employees resulting from their termination as part of a planned workforce reduction, which we undertook to optimize our operations. Additionally, it includes any legal fees incurred as part of the restructuring process. While such actions are not planned going forward as part of our regular operations, we expect such expenses could still be incurred from time to time based on corporate needs. |
Investor Contact:Kellen Sanger IR@sophiagenetics.com Media Contact:Kelly Katapodis media@sophiagenetics.com
Source:
2024 GlobeNewswire, Inc., source