Certain 5.00% Convertible Senior Notes due 2048. of Verastem, Inc. are subject to a Lock-Up Agreement Ending on 14-SEP-2023. These 5.00% Convertible Senior Notes due 2048. will be under lockup for 91 days starting from 15-JUN-2023 to 14-SEP-2023.

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Officers and directors have agreed that we will not offer, sell, contract to sell, pledge or otherwise dispose of any shares of capital stock of the Company or any securities convertible into, or exercisable or exchangeable for such capital stock, or publicly announce an intention to effect any such transaction, without the prior written consent of RBC Capital Markets, LLC and Cantor Fitzgerald & Co., for a period of 90 days after the date of this prospectus supplement.