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JEOL : Researchers Submit Patent Application, "Magnetic Coupling High Resolution Nuclear Magnetic Resolution Probe and Method of Use", for Approval (USPTO...

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02/15/2018 | 06:58pm CET

Researchers Submit Patent Application, "Magnetic Coupling High Resolution Nuclear Magnetic Resolution Probe and Method of Use", for Approval (USPTO 20180031499)

By a News Reporter-Staff News Editor at Health & Medicine Week -- From Washington, D.C., NewsRx journalists report that a patent application by the inventor ZENS, ALBERT (Peabody, MA), filed on April 8, 2016, was made available online on February 8, 2018 (see also JEOL Ltd.).

The patent's assignee is JEOL Ltd.

News editors obtained the following quote from the background information supplied by the inventors: "Structural elucidation of a compound, whether a synthesis product or an extract from a natural source generally requires a number of analytical techniques. Infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy can provide extensive chemical information. NMR can provide structural information and also information on both intermolecular and intramolecular dynamics. Applications of NMR range from determination of three-dimensional structures of large proteins to the analysis of very small amounts of products from combinatorial syntheses. Furthermore, NMR is a nondestructive analytical method.

"High resolution NMR probes typically have an 'inner coil' for irradiation and detection of a first nuclear species, and a second larger coil, coaxial with the inner coil, for irradiation of one or more other nuclear species. The two coils are oriented 90.degree. with respect to each other to minimize coupling between the two coils. Capacitive coupling has previously been used to form double-tuned high resolution NMR probes for .sup.1H-.sup.2H, .sup.13C-.sup.15N and .sup.1H-.sup.19F.

"In U.S. Pat. No. 3,789,832 to Damadian a method for imaging is described in which spatial localization is achieved by means of applying a spatially inhomogeneous static magnetic field where the signal is measured in the small homogeneous region of the static field. In U.S. Pat. No. 4,301,410 to Wind et al., a method is disclosed for spin imaging solids using NMR spectroscopy by rotating the sample about an axis at a particular angle to the NMR static external magnetic field, with a magnetic field gradient with a spatial distribution which is related to the sample spinning axis is synchronously rotated with the sample. In U.S. Pat. No. 4,654,593 to Ackerman, a method for NMR imaging uses a nonmagnetic moving object positioned in the field of a RF excitation coil and a magnetic field where the object is of a low conductivity so as to be substantially transparent to electromagnetic radiation at the NMR frequency and the nonmagnetic object is subjected to periodic motion while transverse magnetization is generated, and a short duration phase-encoding magnetic field gradient pulse is applied in a specified direction to the moving nonmagnetic object, where the magnetic field gradient is turned off and a free induct ion decay signal is detected. In U.S. Pat. No. 5,227,724 to Cory et al., a method for measuring the distribution of the extent of molecular transport along two orthogonal directions, and further for measuring the anisotropy of molecular transport is disclosed. In U.S. Statutory Invention Registration. No. H1218 to Cory et al., a method of NMR imaging where spatial coupling of the sample with a receiver device is varied using pulsed magnetic field gradients and the sample is moved relative to the receiver device, or the spatial coupling of the receiver device and the sample is electronically altered, is disclosed. Kuhns, P. L. et al. describe the use of inductive coupling for series linked tuning of resonant circuits, J. Magnetic Resonance, 'Inductive Coupling and Tuning in NMR Probes: Applications', 78 (1988) 69-76. Hoult, D. I. and Tomanek, B. describes the use of mutually inductive coils and investigates field strength, losses and signal to noise, 'Use of Mutually Inductive Coupling in probe Design', Concepts in Magnetic Resonance, 15(4) (2002) 262-285, Wiley Periodicals, Inc."

As a supplement to the background information on this patent application, NewsRx correspondents also obtained the inventor's summary information for this patent application: "A new problem in the NMR field is that prior art devices using capacitive coupling produce double tuned NMR probes, which do not provide sufficient sensitivity for many uses, especially for obtaining NMR spectra of complex molecules. This problem has been solved by the creation of a new type of inductive coupling coil that can provide a double resonance circuit without the disadvantages of prior art coils. Therefore, in various embodiments of the present invention, an inductive coupling coil can be used to achieve a double-tuned circuit. In various embodiments of the present invention, circuits use inductive coupling to achieve a double resonance circuit for .sup.1H, .sup.19F, .sup.13C (i.e., HFC) experiments where one of the three nuclei are observed and the other two decoupled or some subset of these experiments (i.e., .sup.1H{.sup.19F} or .sup.19F{.sup.1H})."

For additional information on this patent application, see: ZENS, ALBERT. Magnetic Coupling High Resolution Nuclear Magnetic Resolution Probe and Method of Use. Filed April 8, 2016 and posted February 8, 2018. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220180031499%22.PGNR.&OS=DN/20180031499&RS=DN/20180031499

Keywords for this news article include: Business, JEOL Ltd., Electronics, Capacitive Coupling, Health and Medicine, Diagnostics and Screening, Nuclear Magnetic Resonance, Diagnostic Technology Companies, Scientific and Technical Instrument Companies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC

(c) 2018 NewsRx LLC, source Health Newsletters

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Sales 2018 103 B
EBIT 2018 -
Net income 2018 1 618 M
Debt 2018 17 250 M
Yield 2018 0,90%
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P/E ratio 2019 28,66
EV / Sales 2018 0,91x
EV / Sales 2019 0,85x
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