Alligator Bioscience announced the publication of a scientific article featuring its novel bispecific antibody format RUBY® in the peer-reviewed journal mAbs. RUBY® is a novel bispecific antibody format with excellent functionality including IgG-like stability, pharmacology and developability properties. The RUBY® format allows rapid generation of bispecific antibodies (bsAbs) that fulfill key drug development criteria and mitigates many of the challenges associated to other bsAb formats.

The article, entitled "RUBY® - A tetravalent (2+2) bispecific antibody formats with excellent functionality and IgG-like stability, Pharmacology and developability properties, highlights how: RUBY® allows rapid generation of bsAbs with high developability; RUBY® bsAbs are compatible with small-scale production systems for screening purposes, can be produced at high yields from production cell lines, contain low amounts of aggregates, display favorable solubility and stress endurance profiles, are compatible with various IgG isotypes, and allows for tailored Fc gamma receptor interactions; Retained interaction with Fc neonatal receptors is demonstrated to translate into a mAb-like pharmacokinetic profile; Functionality of conditionally active RUBY® bsAbs is confirmed in vitro, and RUBY® bsAbs are shown to penetrate and localize to tumor tissue in vivo.