Amarantus Bioscience Holdings, Inc. announced that positive results from in vitro and animal studies on MANF in the treatment of Wolfram Syndrome. The abstract entitled ˜Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF), A New Therapeutic Target for Wolfram Syndrome,™ describes positive results that show MANF. Activates proliferation of beta cell in WFS1 genetic animal models of Wolfram Syndrome, Suppresses key apoptosis and proteins misfolding and Activates the pro-survival and pro-protein folding mTOR/S6K signaling pathway.