InMed Pharmaceuticals Inc. announced additional preclinical data demonstrating INM-901's positive pharmacological effects in the potential treatment of Alzheimer's disease ("AD"). The recent results demonstrating pharmacological effects in vivo disease models continue to validate INM-901 as a potential treatment of AD. The development of INM-901 may address several pathological factors including neuroinflammation, neuroprotection and neuritogenesis.

Several preclinical studies were conducted in well-characterized AD models. A summary of recent INM-901 preclinical study results includes: INM-901 is a preferential signaling agonist of the CB1/CB2 receptors and impacts the PPAR signaling pathway. INM-901 demonstrates reduced neuroinflammation and improved neuronal function.

INM-901 mRNA data supports the observations made in the previously released behavior studies in locomotor activity, cognition and memory. Previous studies of INM-901 showed the potential to target several biological pathways associated with AD, including neuroprotection to the differentiated neuronal cells from beta-amyloid peptide-induced toxicity and improvement of neuronal function via extension of neurite length, a potential breakthrough in the treatment of AD. The role of CB1, CB2 and PPAR in the treatment of Alzheimer's. CB1 and CB2 receptors are both part of the endocannabinoid system and are found throughout the body, including in the brain.

CB1 receptors are primarily located in the central nervous system, particularly in areas involved in memory, cognition and motor function, while CB2 receptors are involved in modulating neuroinflammation and immune responses. Activation of CB1 and CB2 receptors has been shown to have neuroprotective effects, meaning they can help protect brain cells from damage and death. In AD, where neuronal death is a hallmark feature, enhancing the activity of these receptors may help to slow down the progression of the disease.

Activation of these receptors and other cellular receptors has also been shown to have an impact on neuroinflammation. As neuroinflammation is also believed to contribute to the progression of AD, targeting these receptors could help alleviate this inflammatory response. Several large pharmaceutical companies such as Eli Lilly, Roche, AbbVie, Eisai and Biogen lead research and commercialization efforts in AD drug development.