Lisata Therapeutics, Inc. announced treatment of the first patient in the Cholangiocarcinoma cohort of the BOLSTER Trial by Dr. Ian Hu, a principal investigator of the study, at The University of Texas MD Anderson Cancer Center in Houston, Texas. The Company had previously announced the first patient in the head and neck squamous cell carcinoma cohort of the study had been treated. The BOLSTER trial is a Phase 2a, double-blind, placebo-controlled, multi-center, randomized study evaluating LSTA1 when added to standard-of-care ("SOC") versus SOC alone in patients with either advanced second-line head and neck squamous cell cell carcinoma, second-line esophageal squamous cell carcinoma, or first-line cholangiocarcinomas.

LSTA1 actuates this active transport system in a tumor-specific manner, resulting in systemically co-administered anti-cancer drugs more efficiently penetrating and accumulating in the tumor. LSTA1 also has the potential to modify the tumor microenvironment, with the objective of making tumors more susceptible to immunotherapies. LSTA1 has demonstrated favorable safety, tolerability and activity in clinical trials to enhance delivery of SOC chemotherapy for pancreatic cancer.

The company is exploring the potential of LSTA1 to enable a variety of treatment modalities to treat a range of solid tumors more effectively.