Lisata Therapeutics, Inc. and WARPNINE Incorporated announced the treatment of the first patient in the iLSTA Trial of Lisata's LSTA1 in combination with standard-of-care chemotherapy and immunotherapy as a first-line treatment in locally advanced non-resectable pancreatic ductal adenocarcinoma (PDAC). The iLSTA Trial is a 30-patient, randomized, single-blind, single-center, safety and pharmacodynamic phase 1b/2a study evaluating LSTA1 in combination with the checkpoint inhibitor, durvalumab, plus standard-of-care chemotherapy, nab-paclitaxel and gemcitabine, versus standard-of-care alone in patients with locally advanced non-resectable PDAC. As the study sponsor, WARPNINE will provide all funding and manage all recruitment activities for the study while Lisata will provide the study drug, LSTA1, as well as regulatory support.

WARPNINE and Lisata will share use of the data with the goal of advancing development of LSTA1 toward registration to the benefit of patients in need.