NanoViricides, Inc. explained that the demonstration of strong safety and tolerability of NV-CoV-2 oral drug products has implications beyond COVID, setting the Company up for long term success and growth. NV-CoV-2 drugs contain the active pharmaceutical ingredient NV-387. NV-387 is an ultra-broad-spectrum antiviral nanomedicine that is designed by copying a common host-side chemical signature used by viruses to effectively infect and cause disease in the human and animal hosts.

The Susceptible Viruses Cannot Escape NV-387 Even As They Continue to Evolve in the Field Enabling them to Anticipate that Nanoviricide Drugs Could Have Many Decades Long "Life of Service". No matter how much the virus changes, it continues to use the same host-side signature to bind to and cause infection in the hosts, and thus the nanoviricide would be anticipated to continue to be effective. Thus NV-387 and other antiviral drugs designed on the nanoviricides platform can be expected to have a long duration of effective usability against the target viruses, reaching into several decades, similar to antibiotics, but in stark contrast with current antiviral approaches.

The nanoviricide technology involves copying the invariant and essential host-side signature and, using this signature, building a direct-acting antiviral that destroys the virus. This design feature of nanoviricides solves the most intractable issue in antiviral response, that of viruses escaping the vaccines, antibodies, and small chemical drugs. Ultra-Broad-Spectrum Antiviral Nanomedicines Enabled by the Nanoviricides Platform Would Open Up Very Large Market Sizes.

In addition, NV-387 is designed using the host-side signature that over 90% of human pathogenic viruses use for creating a successful infection in the human or animal hosts. This means NV-387 is likely to be active against a large number of viruses and could be sufficiently active against many of them to become a successful clinical drug against them. There is no drug for general treatment of RSV infection at present, enabling NV-387 to be a candidate for this $1.8 Billion to $8 Billion annual market size as estimated by GrowthPlus Reports.

There is a strong interest in developing additional antivirals against Smallpox, because of the potential bioterrorism threat. It is known that Smallpox virus can escape the approved drug tecovirimat by a single point mutation. COVID is here to stay, and even as the pandemic has largely subsided, the need for COVID therapeutics is in the range of tens of billions of dollars.

Long COVID also remains a problem that effective antiviral such as NV-387 could make a difference in. NV-387 is designed to mimic the host-side signature called "Sulfated Proteoglycans" ("S-PG"). This signature is used by over 90% of human pathogenic viruses, a very long list indeed.

Success against a few of these viruses could build NV-387 into a drug that targets over $20 Billion market size. The Strong Safety of NV-387 Is Expected to Enable Its Use Across All Patients. The strong safety and tolerability of NV-387 demonstrated in human clinical trial implies that it can be used: (i) across all ages from pediatrics to seniors; (ii) irrespective of co-morbidities such as diabetes, other pre-existing diseases, or immune compromised status of the individual; and (iii) at all levels of disease severity, from mild/moderate to severe to very severe (hospitalized patients).

This capability of NV-387 is analogous to the highly successful antibiotics against bacteria. In contrast, currently available antiviral drugs have strong limitations on the patient populations that they can be used in. For example, of the two remaining approved drugs for treatment of COVID, Paxlovid which is given orally, is not indicated for the treatment of COVID-19 in patients without a risk factor for progression to severe COVID-19, whereas Remdesivir can only be used in hospitalized cases.

Antibiotics caused a major revolution in how the company treat bacterial infections, with the discovery of the broad-spectrum antibacterial, penicillin. Penicillin attacks the chemical signature common to whole classes of bacteria. Thereby it attacks the bacterial surface and causes dismantling of the bacteria.

Analogously, NV-387 uses a common feature to which a large number of viruses bind. By displaying this feature on top of the "shape-shifting" nanoviricide polymeric micelle, NV-387 is designed to attack and dismantle the viral particle. This is what gives NV-387 the broad-spectrum antiviral capabilities.

The success of penicillin led to an explosion in development of antibacterials that use the same mechanism of action and provide additional benefits, stronger activity against certain bacteria and oral administration amongst them. In fact, the world continues to use amoxicillin to treat most pediatric and adult bacterial infections to this day, some 65 years since its discovery in 1958! This durability is a direct result of the fact that most of the bacteria it attacks have not escaped the drug and have remained susceptible even after such a long time of common use.

This comparison of features of nanoviricides technology platform and, in particular, NV-387, with the revolutionary antibiotics development against bacteria argues that NanoViricides is now on a solid footing to revolutionize treatment of antiviral infections.