Item 5.08 Shareholder Director Nominations.

To the extent applicable, the information in Item 8.01 of this Current Report on Form 8-K is incorporated by reference into this Item 5.08.

Item 8.01 Other Events.

On September 29, 2022, the Board of Directors of Nuo Therapeutics, Inc. (the "Company") determined that the Company's 2022 Annual Meeting of Stockholders (the "Annual Meeting") will be held at the Company's principal executive office at 8285 El Rio, Suite 190, Houston, Texas on December 2, 2022, or as otherwise set forth in the Company's notice and proxy statement for the Annual Meeting to be filed no less than 40 days prior to the Annual Meeting. Stockholders of record of the Company's common stock as of the close of business on September 30, 2022 will be entitled to notice of, and to vote at, the Annual Meeting.

Stockholders of the Company who wish to have a proposal, including nominations of persons for election to the Board of Directors, considered for inclusion in the Company's proxy materials for the Annual Meeting must ensure that such proposal is received by, on or before the close of business on October 10, 2022, which date the Company has determined to be a reasonable time before it expects to begin to print and send its proxy materials, and which complies with the requirements of the Amended and Restated By-Laws of the Company as adopted May 5, 2016 (the "By-Laws"). To be eligible for inclusion in the proxy materials for the Annual Meeting, any such proposal must also meet the requirements set forth in the rules and regulations of the Securities and Exchange Commission and in the By-Laws. Proposals and notices must be in writing and received by the Company's Secretary, David Jorden, addressed to: Nuo Therapeutics, Inc. Board of Directors, Attn: Secretary, 8285 El Rio, Suite 190, Houston, Texas 77054.

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