On February 16, 2023, Skye Bioscience, Inc. filed a Current Report on Form 8-K to report the appointment of Dr. Deborah Charych, Ph.D. as a director of the Company's Board of Directors. At the time of the Initial 8-K, the Board had not determined the committees on which Dr. Charych would serve, if any. This Amendment No.

1 to the Initial 8-K is being filed to report that on March 21, 2023, the Board appointed Dr. Charych to serve on the Nominating and Corporate Governance Committee of the Board, effective immediately.