Recent Research from Philip Morris International Inc Highlight Findings in Pharmacokinetics (Nicotine pharmacokinetic profiles of the Tobacco Heating System 2.2, cigarettes and nicotine gum in Japanese smokers)
By a News Reporter-Staff News Editor at China Weekly News -- Investigators publish new report on Pharmacokinetics. According to news reporting from Neuchatel, Switzerland, by VerticalNews journalists, research stated, "Two open-label randomized cross-over studies in Japanese smokers investigated the single-use nicotine pharmacokinetic profile of the Tobacco Heating System (THS) 2.2, cigarettes (CC) and nicotine replacement therapy (Gum). In each study, one on the regular and one on the menthol variants of the THS and CC, both using Gum as reference, 62 subjects were randomized to four sequences: Sequence 1: THS - CC (n = 22); Sequence 2: CC THS (n = 22); Sequence 3: THS Gum (n = 9); Sequence 4: Gum THS (n = 9)."
The news correspondents obtained a quote from the research from Philip Morris International Inc, "Plasma nicotine concentrations were measured in 16 blood samples collected over 24 h after single use. Maximal nicotine concentration (C-max) and area under the curve from start of product use to time of last quantifiable concentration (AUC(0-last)) were similar between THS and CC in both studies, with ratios varying from 88 to 104% for C-max and from 96 to 98% for AUC(0-last). Urge-to-smoke total scores were comparable between THS and CC. The THS nicotine pharmacokinetic profile was close to CC, with similar levels of urge-to-smoke."
According to the news reporters, the research concluded: "This suggests that THS can satisfy smokers and be a viable alternative to cigarettes for adult smokers who want to continue using tobacco."
For more information on this research see: Nicotine pharmacokinetic profiles of the Tobacco Heating System 2.2, cigarettes and nicotine gum in Japanese smokers. Regulatory Toxicology and Pharmacology, 2017;89():193-199. Regulatory Toxicology and Pharmacology can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Regulatory Toxicology and Pharmacology - www.journals.elsevier.com/regulatory-toxicology-and-pharmacology/)
Our news journalists report that additional information may be obtained by contacting R. Weitkunat, Philip Morris Prod SA, PMI R&D, CH-2000 Neuchatel, Switzerland. Additional authors for this research include P. Brossard, V. Poux, N. Lama, C. Haziza, P. Picavet, G. Baker and F. Ludicke.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.yrtph.2017.07.032. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Keywords for this news article include: Neuchatel, Switzerland, Europe, Pharmacokinetics, Pharmaceuticals, Asia, Philip Morris International Inc.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC